INVESTIGATING LEPTIN RESISTANCE IN MORBID OBESITY AND TYPE 2 DIABETES

Abstract

Leptin resistance has emerged as a critical factor in the pathogenesis of type 2 diabetes mellitus (T2DM), particularly in the context of morbid obesity. This study aimed to investigate the associations between leptin resistance, metabolic markers, and inflammatory parameters in individuals with T2DM and varying degrees of obesity. Patients who had both T2DM and morbid obesity (BMI greater than 40), those with T2DM but not morbidly obese (BMI below 40) and non-diabetic controls were all part of the study.  Serum leptin, glucose, insulin, HOMA-IR, CRP, IL-6 and HbA1c were looked at using blood samples taken after a fast and anthropometric measurements.  To perform the analyses, I used both group comparisons and correlation studies.  When comparing to only T2DM or control participants, participants with morbid obesity along with T2DM had higher average levels of leptin (60.37 ± 9.75 ng/mL), insulin (24.87 ± 5.12 µIU/mL) and HOMA-IR score (11.01 ± 1.93).  Records from the morbidly obese diabetes group also indicted rise in inflammatory factors: CRP (9.91 ± 2.13 mg/L) and IL-6 (8.03 ± 2.07 pg/mL.).  Because the HbA1c level in this group was the highest (9.02 ± 1.04%), there were clear difficulties in ongoing glucose control.  By examining the results, we noticed that there were strong favorable correlations among leptin, insulin, HOMA-IR and BMI.  In addition, it was pointed out that resistance to leptin can hurt insulin and its function.  Even more connections were found between parenting and behavior by using visual graphs.  This finding suggests that morbid obesity markedly reduces leptin levels which also increases insulin resistance, inflammation in the body and hyperglycaemia in those with T2DM.  Such discoveries demonstrate that including leptin-based treatments may benefit the therapy of obese diabetic populations.